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The finding of Malignant Melanoma Cure
Good news for us, scientists has developed a drug that can treat melanoma, the most deadly form of skin cancer in its most advanced, incurable stages. They called this melanoma drug PLX4032 (R7204).
PLX4032 is still experimental drug, due to research it could help many patients with incurable disease live longer with the disease in check, early trial results suggest. Roche and Plexxikon presented the work at a renowned US cancer meeting.
These drugs will also helping skin cancer patient in UK, since malignant melanoma is the most rapidly increasing cancer in the UK, largely due to sun exposure.
PLX4032 works by seeking out and destroying tumor cells carrying the BRAF mutation implicated in 60% malignant melanomas. This could not only help to shrink the skin cancer, but also delay its spread. Currently, only a small proportion of people - less than 5% - live more than two years if their cancer has spread around the body.
Main article - Melanoma Skin Cancer Facts
30 Mayıs 2012 Çarşamba
Basal Cell Carcinoma Skin Cancer Treatment Options
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Basal cell carcinoma skin cancer is the most common type of skin cancer, although it's rarely kills its victims, the disfigurement that caused by basal cell carcinoma is quite distressing.
Basal cell carcinoma skin cancer usually treats with the following skin cancer treatment:
Some people claimed that Moh's Surgery has a very high cure rate as skin cancer treatment, up to 98%. Moh's surgery works by surgically excising the tumor and then immediately examined under a microscope. The base and edges are microscopically examined to verify sufficient margins before the surgical repair of the site. If the margins are insufficient, more is removed from the patient until the margins are sufficient. Moh's surgery is also used for squamous cell carcinoma, however, the cure rate is not as high as Moh's surgery for basal cell carcinoma.
Chemotherapy
Chemotherapy as skin cancer treatment usually uses 5-fluorouracil. Skin cancer topical treatment with 5% Imiquimod cream, with five applications per week for six weeks has a reported 70-90% success rate at reducing, even removing, the basal cell carcinoma skin cancer. Chemotherapy often used after Moh's surgery to eliminate the residual superficial basal cell carcinoma after the invasive portion is removed.
Standard surgical excision
Standard surgical excision is the most preferred method in treating basal cell carcinoma, even among all basal cell carcinoma skin cancer treatment. The cure rate of this skin cancer treatment depends on surgical margin, and when standard surgical margin is applied (usually 4 mm or more), a high cure rate can be achieved with standard excision.
Immunotherapy
Immunotherapy research suggests that treatment using Euphorbia peplus, a common garden weed, may be effective. Australian biopharmaceutical company Peplin is developing this as topical treatment for BCC.
Radiation
Radiation therapy can be used to treat all type of basal cell carcinoma skin cancer. The cure rate that radiation has is up to 95% for small tumor, or 80% for big tumor.
Main Article: Basal Cell Carcinoma Skin cancer
Basal cell carcinoma skin cancer usually treats with the following skin cancer treatment:
- Moh's Surgery
- Chemotherapy
- Standard Surgical Excision
- Immunotherapy
- Radiation
Some people claimed that Moh's Surgery has a very high cure rate as skin cancer treatment, up to 98%. Moh's surgery works by surgically excising the tumor and then immediately examined under a microscope. The base and edges are microscopically examined to verify sufficient margins before the surgical repair of the site. If the margins are insufficient, more is removed from the patient until the margins are sufficient. Moh's surgery is also used for squamous cell carcinoma, however, the cure rate is not as high as Moh's surgery for basal cell carcinoma.
Chemotherapy
Chemotherapy as skin cancer treatment usually uses 5-fluorouracil. Skin cancer topical treatment with 5% Imiquimod cream, with five applications per week for six weeks has a reported 70-90% success rate at reducing, even removing, the basal cell carcinoma skin cancer. Chemotherapy often used after Moh's surgery to eliminate the residual superficial basal cell carcinoma after the invasive portion is removed.
Standard surgical excision
Standard surgical excision is the most preferred method in treating basal cell carcinoma, even among all basal cell carcinoma skin cancer treatment. The cure rate of this skin cancer treatment depends on surgical margin, and when standard surgical margin is applied (usually 4 mm or more), a high cure rate can be achieved with standard excision.
Immunotherapy
Immunotherapy research suggests that treatment using Euphorbia peplus, a common garden weed, may be effective. Australian biopharmaceutical company Peplin is developing this as topical treatment for BCC.
Radiation
Radiation therapy can be used to treat all type of basal cell carcinoma skin cancer. The cure rate that radiation has is up to 95% for small tumor, or 80% for big tumor.
Main Article: Basal Cell Carcinoma Skin cancer
Basal Cell Treatment Standard Surgical Excision
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Standard surgical excision usually uses either:
This skin cancer treatment has a weakness that is a high recurrence rate of basal cell cancers of the face, especially around eyelids, nose, and facial structures. On the face, or on recurrent basal cell cancer after previous surgery, special surgical margin controlled processing (Mohs surgery is one of the methods) is required. With surgical margin controlled frozen section histology, a surgeon can achieve a high cure rate and low recurrence rate on the same day of the excision.
However, most standard surgical excisions done in a plastic surgeon or dermatologist's office are sent to an outside laboratory for standard bread loafing method of processing. This method has a high "false negative" rate due to the random sampling of the tumour. For cosmetic reasons, many doctors take only very small surgical margins 1-2 mm, especially when facial tumour is being removed. A pathology report from such a case indicating "margins free of residual tumour", often is inaccurate, and a high recurrence rate of up to 38% might occur.
When in doubt, a patient should demand that either Mohs surgery or frozen section histology with either margin control or thin serial bread-loafing is utilized when dealing with a tumour on the face. The pathologist processing the frozen section specimen should cut multiple sections through the block to minimize the false negative error rate. Or one should simply process the tissue utilizing a method approximating the Mohs method during frozen section processing.
However, this method is difficult when applied to frozen sections; and is very tedious to process. When not utilizing frozen section, the patient might have to wait a week or more, before informing the patient if more tumors are left, or if the surgical margin is too narrow. And a second surgery must be performed to remove the residual or potential residual tumour once the surgeon inform the patient of the positive or narrow surgical margin on the surgical pathology report.
Main Article - Basal Cell Carcinoma Treatment Option
- Frozen section histology, or
- Parafin embedded fixed tissue pathology
This skin cancer treatment has a weakness that is a high recurrence rate of basal cell cancers of the face, especially around eyelids, nose, and facial structures. On the face, or on recurrent basal cell cancer after previous surgery, special surgical margin controlled processing (Mohs surgery is one of the methods) is required. With surgical margin controlled frozen section histology, a surgeon can achieve a high cure rate and low recurrence rate on the same day of the excision.
However, most standard surgical excisions done in a plastic surgeon or dermatologist's office are sent to an outside laboratory for standard bread loafing method of processing. This method has a high "false negative" rate due to the random sampling of the tumour. For cosmetic reasons, many doctors take only very small surgical margins 1-2 mm, especially when facial tumour is being removed. A pathology report from such a case indicating "margins free of residual tumour", often is inaccurate, and a high recurrence rate of up to 38% might occur.
When in doubt, a patient should demand that either Mohs surgery or frozen section histology with either margin control or thin serial bread-loafing is utilized when dealing with a tumour on the face. The pathologist processing the frozen section specimen should cut multiple sections through the block to minimize the false negative error rate. Or one should simply process the tissue utilizing a method approximating the Mohs method during frozen section processing.
However, this method is difficult when applied to frozen sections; and is very tedious to process. When not utilizing frozen section, the patient might have to wait a week or more, before informing the patient if more tumors are left, or if the surgical margin is too narrow. And a second surgery must be performed to remove the residual or potential residual tumour once the surgeon inform the patient of the positive or narrow surgical margin on the surgical pathology report.
Main Article - Basal Cell Carcinoma Treatment Option
Basal Cell Carcinoma treatment moh's Surgery
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Mohs Micrographic Surgery or just Mohs Surgery is the most advanced and effective treatment procedure for skin cancer available today. It is an outpatient procedure in which the tumor is surgically excised and then immediately examined under a microscope. It said that Mohs surgery has a high cure rate compared to other skin cancer treatment. It is a good treatment for basal cell carcinoma.
The base and edges are microscopically examined to verify sufficient margins before the surgical repair of the site. If the margins are insufficient, more is removed from the patient until the margins are sufficient.
However, mohs surgery procedure usually performed by specially trained surgeons who have completed at least one additional year of fellowship training (in addition to the physician's three-year dermatology residency) under the tutelage of a Mohs College member.
With the Mohs technique, physicians are able to see beyond the visible disease, to precisely identify and remove the entire tumor layer by layer while leaving the surrounding healthy tissue intact and unharmed. As the most exact and precise method of tumor removal, it minimizes the chance of re-growth and lessens the potential for scarring or disfigurement.
Because the physician is specially trained in surgery, pathology, and reconstruction, Mohs surgery has the highest success rate of all treatments for skin cancer - up to 99 percent. The Mohs technique is also the treatment of choice for cancers of the face and other sensitive areas as it relies on the accuracy of a microscopic surgical procedure to trace the edges of the cancer and ensure complete removal of all tumors down to the roots during the initial surgery. Mohs surgery also used for squamous cell carcinoma; however, the cure rate is not as high as Mohs surgery for basal cell carcinoma.
Main article - Standard Surgical Excision
The base and edges are microscopically examined to verify sufficient margins before the surgical repair of the site. If the margins are insufficient, more is removed from the patient until the margins are sufficient.
However, mohs surgery procedure usually performed by specially trained surgeons who have completed at least one additional year of fellowship training (in addition to the physician's three-year dermatology residency) under the tutelage of a Mohs College member.
With the Mohs technique, physicians are able to see beyond the visible disease, to precisely identify and remove the entire tumor layer by layer while leaving the surrounding healthy tissue intact and unharmed. As the most exact and precise method of tumor removal, it minimizes the chance of re-growth and lessens the potential for scarring or disfigurement.
Because the physician is specially trained in surgery, pathology, and reconstruction, Mohs surgery has the highest success rate of all treatments for skin cancer - up to 99 percent. The Mohs technique is also the treatment of choice for cancers of the face and other sensitive areas as it relies on the accuracy of a microscopic surgical procedure to trace the edges of the cancer and ensure complete removal of all tumors down to the roots during the initial surgery. Mohs surgery also used for squamous cell carcinoma; however, the cure rate is not as high as Mohs surgery for basal cell carcinoma.
Main article - Standard Surgical Excision
Moh's Surgery for Melanoma
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Mohs Surgery is a type of skin cancer treatment that not only has a very high cure rate but also less invasive. Moh’s surgery has a very high cure rate depend on what its treat, it has the highest cure rate when treating basal cell carcinoma skin cancer, but the cure rate is lesser in treating squamous cell carcinoma skin cancer.
Mohs surgery can also be used to treating melanoma. However, moh’s surgery has a higher cure rate if treating melanoma in situ. It has been used in the removal of melanoma-in-situ (cure rate 77% to 98% depending on surgeon), and certain types of melanoma (cure rate 52%). Another study of melanoma-in-situ revealed Mohs cure rate of 95% for frozen section Mohs, and 98 to 99% for fixed tissue Mohs method. In situ is a condition that a cancer is still not become cancer yet.
However, mohs surgery is appropriate when:
Mohs surgery can also be used to treating melanoma. However, moh’s surgery has a higher cure rate if treating melanoma in situ. It has been used in the removal of melanoma-in-situ (cure rate 77% to 98% depending on surgeon), and certain types of melanoma (cure rate 52%). Another study of melanoma-in-situ revealed Mohs cure rate of 95% for frozen section Mohs, and 98 to 99% for fixed tissue Mohs method. In situ is a condition that a cancer is still not become cancer yet.
However, mohs surgery is appropriate when:
- The skin cancer is in an area where it is important to preserve healthy tissue for maximum functional and cosmetic result, such as: eyelids, nose, ears, lips, fingers, toes, genitals.
- The skin cancer was treated previously and recurred.
- Scar tissue exists in the area of the cancer.
- The skin cancer is large.
- The edges of the cancer cannot be clearly defined.
- The skin cancer is growing rapidly or uncontrollably.
26 Mayıs 2012 Cumartesi
Skin Cancer And Sun Beds
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24/04/2012A skin cancer survivor and Health Secretary Nicola Sturgeon today joined forces to issue a new warning about the dangers of unsafe tanning.
The warning comes as figures, published today by ISD Scotland, show a sharp increase in reported cases of melanoma in the last ten years.
Today’s cancer incidence figures show a 62 per cent rise in skin cancer between 2000 and 2010.
The main risk factor for skin cancer is exposure to natural and artificial sunlight, especially at a young age.
Mum-of-one Jacqui Carruthers was diagnosed with malignant melanoma in March 2009 at the age of 29, and is warning about the dangers of using sunbeds.
Jacqui used sunbeds before a night out, or before going on holiday, and would sunbathe with little or no sun protection to give her a ‘healthy glow’.
At the end of 2008 she became aware of a mole on her back that she felt had changed in colour. After a few months she was referred to see a dermatologist at the Royal Alexandra Hospital in Paisley.
A few weeks later a biopsy revealed it was a malignant melanoma and the mole was removed. A week later Jacqui had a wider incision to remove the surrounding tissue and ensure the cancer had not spread.
Ms Sturgeon said: “These figures are yet another stark warning of the dangers of unsafe tanning – either in the sun or using sunbeds.
“People need to realise how essential it is to wear sunscreen and cover up in the sun. Doing this and avoiding sunbed use really could save your life.
“Using sunbeds is dangerous and that is why Scotland led the way by being the first part of the UK to introduce legislation to address the health risks associated with sunbed use.
“Jacqui’s story shows us that you don’t need to use sunbeds regularly to put yourself at risk of skin cancer. I hope people will use her experience as a warning and think very carefully before using sunbeds or going out in the sun without wearing sunscreen.
“The increase in the number of people being diagnosed with melanoma may in part be down to better awareness and improved diagnosis, but there is no doubt that unsafe tanning remains a big issue, particularly among the young.
“We recently launched the Detect Cancer Early campaign – the sooner cancer is treated the better the chances of survival.”
The Public Health (Scotland) Act 2008 banned the use of sunbeds by under 18s and it also required operators to display notices warning of the health risks and to provide information to users of sunbeds on those risks.
Three years on, there is no evidence that Jacqui’s cancer has returned and she no longer has to have regular check ups.
Jacqui, now 32, who lives in Bishopton with husband David, 34, and son Jude, 4, said: “I sunbathed as a teenager and in my 20s. Although I wasn’t a regular sunbed user, I used sunbeds occasionally prior to nights out to make myself look good and have a 'healthy' tanned appearance.
“When I was diagnosed I felt as though my life had been pulled from under me. I was completely naïve and didn’t believe that this could happen to me. I'm not pale skinned and I don’t burn so I didn’t think that skin cancer would ever be an issue.
“I would warn anyone against using sunbeds as they are significantly increasing their risk of getting cancer.”
Chief Medical Officer Sir Harry Burns said:
“Exposure to sunlight, to a certain extent is very important, for the generation and production of vitamin D in the skin, however, it is very important not to get burnt – use sun block and limit your exposure to the sun – that’s the best way of avoiding this particular tumour.
“Survival in Scotland after a diagnosis of this tumour is generally better than in most other European countries. So, it is important that if you have a dark patch on your skin that you think has changed recently or has started to bleed or become itchy you go and see the doctor about it and get the best available treatment.”
From National Health Service, Scottish Government
Skin cancer survivor warns of sunbed danger
The warning comes as figures, published today by ISD Scotland, show a sharp increase in reported cases of melanoma in the last ten years.
Today’s cancer incidence figures show a 62 per cent rise in skin cancer between 2000 and 2010.
The main risk factor for skin cancer is exposure to natural and artificial sunlight, especially at a young age.
Mum-of-one Jacqui Carruthers was diagnosed with malignant melanoma in March 2009 at the age of 29, and is warning about the dangers of using sunbeds.
Jacqui used sunbeds before a night out, or before going on holiday, and would sunbathe with little or no sun protection to give her a ‘healthy glow’.
At the end of 2008 she became aware of a mole on her back that she felt had changed in colour. After a few months she was referred to see a dermatologist at the Royal Alexandra Hospital in Paisley.
A few weeks later a biopsy revealed it was a malignant melanoma and the mole was removed. A week later Jacqui had a wider incision to remove the surrounding tissue and ensure the cancer had not spread.
Ms Sturgeon said: “These figures are yet another stark warning of the dangers of unsafe tanning – either in the sun or using sunbeds.
“People need to realise how essential it is to wear sunscreen and cover up in the sun. Doing this and avoiding sunbed use really could save your life.
“Using sunbeds is dangerous and that is why Scotland led the way by being the first part of the UK to introduce legislation to address the health risks associated with sunbed use.
“Jacqui’s story shows us that you don’t need to use sunbeds regularly to put yourself at risk of skin cancer. I hope people will use her experience as a warning and think very carefully before using sunbeds or going out in the sun without wearing sunscreen.
“The increase in the number of people being diagnosed with melanoma may in part be down to better awareness and improved diagnosis, but there is no doubt that unsafe tanning remains a big issue, particularly among the young.
“We recently launched the Detect Cancer Early campaign – the sooner cancer is treated the better the chances of survival.”
The Public Health (Scotland) Act 2008 banned the use of sunbeds by under 18s and it also required operators to display notices warning of the health risks and to provide information to users of sunbeds on those risks.
Three years on, there is no evidence that Jacqui’s cancer has returned and she no longer has to have regular check ups.
Jacqui, now 32, who lives in Bishopton with husband David, 34, and son Jude, 4, said: “I sunbathed as a teenager and in my 20s. Although I wasn’t a regular sunbed user, I used sunbeds occasionally prior to nights out to make myself look good and have a 'healthy' tanned appearance.
“When I was diagnosed I felt as though my life had been pulled from under me. I was completely naïve and didn’t believe that this could happen to me. I'm not pale skinned and I don’t burn so I didn’t think that skin cancer would ever be an issue.
“I would warn anyone against using sunbeds as they are significantly increasing their risk of getting cancer.”
Chief Medical Officer Sir Harry Burns said:
“Exposure to sunlight, to a certain extent is very important, for the generation and production of vitamin D in the skin, however, it is very important not to get burnt – use sun block and limit your exposure to the sun – that’s the best way of avoiding this particular tumour.
“Survival in Scotland after a diagnosis of this tumour is generally better than in most other European countries. So, it is important that if you have a dark patch on your skin that you think has changed recently or has started to bleed or become itchy you go and see the doctor about it and get the best available treatment.”
From National Health Service, Scottish Government
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